PT-141, also called as Bremelanotide, is a derivative for Melanotan 2 (M2). Unlike M2, PT-141 lacks C-terminal amide molecules. Bremelanotide is a cyclic hepta-peptide lactam derivative of alpha-MSH. PT-141 acts by stimulating melanocortin receptors present in the central nervous system. Due to this potential, PT-141 is being studied as a potential treatment for sexual disorders such as erectile disorders in men and sexual arousal disorders in women. The amino acid structure of PT-141 is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH or cyclo-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH-(4-10). It is not a vasoactive compound, rather acts directly in the higher centers to increase sexual activity. Over 6 years, studies yielded promising results and additional studies are underway to further explore the properties of M2 derivative

PT-141 was developed from Melanotan II and it is a variant of the hormone, which is known to induce melanogenesis, alpha MSH activates specific melanocortin receptors, which in turn produces melanin. Actually, MSH has potent influence over appetite, libido, and lipid metabolism and there have been research and studies to ascertain its effects in curing various sexual dysfunction related conditions. Research reveals that PT-141 has no effect on the vascular system like other compounds; however, it works on melanocortin receptors in the brain and in turn increases the sexual stimulation through positive feedback mechanism. Studies on mice showed that female rats responded to higher dosage of the polypeptide when compared to the male rats. PT- 141 was developed from Melanotan 2 Good quality Pt-141 which is reconstituted using bacteriostatic water can be preserved for a period of 6 to 12 months. The vials should be stored under refrigerated conditions (2 to 8 degrees centigrade).

PT-141 Chemical Profile

CAS: 32780-32-8
Formula: C50H68N14O10
Molecular weight: 1025.2
Peptide purity: > 99.0%
Chain: CH3CO-Nle-[Asp-His-(d)-Phe-Arg-Trp-Lys]-COOH