Description

MGF (Mechano Growth Factor) is a variant of IGF-1 (Insulin-Like Growth Factor-1), also available as a synthetic, water-based variant with less stability. MGF is generally derived from exercised or injured/damaged muscle tissue. The biomolecule mimic IGF gene expression that augments stem cell population in the muscle tissue to promote hyperplasia. The addition of polyethylene glycol (PEG) with the compound prevents spontaneous degradation in the bloodstream and increases plasma half-life. PEG-MGF is a variant of IGF, which is produced by the shift of the IGF gene, and the PEGylation of the molecule, which is essential for improving its stability. PEGylated Mechano factor is the new form of IGF and the hormone functions by increasing the formation of new muscle cells. When the stem cells are increased the muscle mass increases effectively.

Synthetic MGF travels through the bloodstream and is not affected by the condition of the serum although it has a short half-life when in contact with serum. The PEGylation or addition of a polyethene glycol molecule to the structure is essential in increasing the potency , activity and effectiveness of PEG-MGF. The PEG acts a protective coat, which prevents degradation of the polypeptide from the internal enzymes and other chemical factors. Moreover, the polyethylene glycol molecules offer more binding sites to the molecule which allows for increased affinity to the perfect ligand during interactions. The polypeptide is usually negatively charged and any positively charged compound would affect its integrity and activity, therefore, reducing its lifespan, however, with the enhanced coat the lifespan and activity is enhanced to an optimal level. There are various research and studies conducted on the use of the polypeptide in enhancing muscle hyperplasia.

PEG-MGF Chemical Profile Formula: C121H200N42O39

Molecular weight: 2888.16

Chain: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys