Melanotan 2 (MT-2) is a man-made version of alpha melanocyte stimulating hormone (MSH), a melanocortin peptide hormone. It was first synthesized by researchers at the University of Arizona for melanogenesis, and to increase libido effects in men. The peptide mimics melanogenesis and UV-protective effects of Melanotan 1. However, recent research evidences suggest aphrodisiac effects of Melanotan 2. Due to protective effects against harmful UV rays, it is being studied as a potential prophylaxis against melanoma (skin cancer). The synthetic chemical is contraindicated for consumption, diagnosis or treatment in humans, and strictly for research purpose only. The molecular weight and formula is 1024.2 and C50H69N15O9, respectively.

Studies indicate that MSH has a considerable effect on appetite, lipid metabolism, and sexual libido via the melanocortin receptors. Studies have been done to determine its effectiveness as appetite suppressant, libido enhancing properties and appetite suppressant properties. Moreover, Melanotan 2 has shown efficacy in combating erectile dysfunction and other sexual dysfunction related conditions.Melanotan II has shown to be effective in increasing libido, and has aphrodisiac properties. The hormone is a cyclic heptapeptide analog of alpha MSH. Research indicates that Melanotan 2 activates the central melanocortin, which in turn triggers melanogenesis, and skin tanning occurs. Melanotan II reduces the serum levels of cholesterol and insulin, moreover further studies indicate that it lowers the levels of acetylcholine, a carboxylase expression and in other cases, it inhibited the reduction of palmitoltransferase I mRNA, and carnitine. This shows that the hormone increases cholesterol metabolism and fat catabolism.

Studies show that Melanotan 2 can be effective in treating polymorphous eruption and actinic keratosis, the common skin conditions that are characterized by intolerance to sunlight. Exposure to the sun results in burning sensation, severe sores, itchiness, lumps, dry skin among others. Melanotan 2 cannot treat albinism because the albinos have no melanocortin receptors therefore the hormone will not be able to bind and induce tanning.

Melanotan 2 Chemical Profile

CAS: 121062-08-6
Formula: C50H69N15O9
Molecular weight: 1024.2
Peptide purity: > 99.0%
Chain: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2(cyclic 2-7)