Melanotan 1 is a naturally occurring melanocorticotrophic hormone that induces melanogenesis (skin pigmentation). Melanotan 1, also called Afamelanotide, protects skin from harmful sunrays and UV damage by non-selective binding with melanocortin receptors. The biochemical was synthesized by scientists at the University of Arizona. The efficacy of Melanotan 1 is 1000 times more potent than naturally occurring alpha-MSH. Research studies are underway to explore the protective role of Melanotan 1 against harmful UV rays and radiation, by stimulation of skin tan and pigmentation. The action of the biomolecule mimics natural skin tanning and protects the skin cells from harmful rays. The molecular mass is 1646.88 and molecular formula C78H111N21O19. Alpha melanocortin stimulating hormone utilizes the melanocortin receptors in exerting its effects, research reveals that MSH has a potent influence on appetite, lipid metabolism, and sexual libido among other essential functions.

The selective agonist acts on receptors MC 3, MC1, MC4, and MC 5. The peptide was initially called Melanotan thereafter it became Melanotan 1 , Melanotan I gives the body the protective effect against effects of ultra violet rays of the sun. The hormone triggers a signaling cascade, which leads to the activation of MC1R on the melanocytes, or cells that produce melanin. When Melanotan binds to the receptors melanocytes on the epidermal layer of the skin accentuates the start of a series of reactions that results in the production of eumelanin a brown-black pigment. The pigment protects the skin from harmful UV rays , microphtalmia associated transcription factor gene is essential in activating other genes which  are vital in melanogenesis.The production of eumelanin instead of pheomelanin by the skin cells increases the pigmentation of the skin, this pigmentation is essential in protecting the skin against harmful ultraviolet radiation. Other studies show that Melanotan is vital in treating of erythropoietic photoporphyria, which is intolerance to light.

Melanotan 1 Chemical Profile

CAS: 75921-69-6
Formula: C78H111N21O19
Molecular weight: 1646.88
Peptide purity: > 99.0%
Chain: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2