Frag 176-191 is a modified amino acid sequence of growth hormone. The lipolytic activity of Frag 176-191 was confirmed by several published studies. The compound acts directly on the adipose fat tissues, increasing lipolysis and decreasing lipogenesis. Studies are being conducted on the compound since the early 1970’s. Frag 176-191 is rich in proline and proteases, as reported by a study published in 1984. Although, the compound mimics the properties of growth hormones, the former do not influence blood glucose levels. The compound’s molecular mass is 1871.1 and molecular formula is C78H125N23O23S2. The polypeptide is the most active part in the long HGH polypeptide chain.

The fragment is less than ten percent of the total size of GH; researchers have found the properties of the fragment to be effective in lipolysis as it mimics the activity of the natural growth hormone. The mechanism of action is through inhibition of lipogenesis while encouraging lipolysis. Moreover, it has no effect on the levels of insulin like growth factors. Fragment 176-191 exhibits high ability to burn stubborn adipocytes while increasing muscle mass, energy expenditure, and oxidation of fats.  The segments of the synthetic peptide HGH 176-191 have shown considerable effects in increasing blood glucose with other fragments such as 172-191,178-191 and 177-191. Moreover, studies reveal that the functionality of the polypeptide does not only depend on the correct physical configuration but also the informational sequence of the polypeptide sequence. The cytoplasmic domain acts a hinge to support the two other domains, which enhances the binding sites of the polypeptides by presenting the active sites to ligand for high affinity binding.

Frag 176-191 Chemical Profile

Formula: C78H125N23O23S2
Molecular weight: 1817.12
Peptide purity: > 99.0%
Chain:H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH